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KMID : 0191119940090010021
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Journal of Korean Medical Science
1994 Volume.9 No. 1 p.21 ~ p.28
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Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients
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Kim YJ
Park HS
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Abstract
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To evaluate the significance of chironomid as a respiratory allergen, we performed skin
prick tests with Chironomus plumosus (CP) and Tokunagayusurika akamusi (TA) extracts on 475 respiratory allergy patients, and their specific IgE antibodies were detected by
enzyme-linked immunosorbent assay (ELISA) in 106 positive reactors to skin prick test
and 30 negative controls. Ninety-seven (20.4%) showed more than 2+ of allergen to histamine ratio to CP and 98 (20.6%) to TA on skin prick test. Seventy-one (73.2%) of 97 positive reactors had increased specific IgE to CP, and 34 (34.7%) of 98 positive reactors, to TA. CP-specific IgE was detected in 14 (14.4%) non-atopic asthmatics and 6 (6.2%) non-allergic rhinitis patients. TA-specific IgE was detected in 17 (17.4%) non-atopic asthmatics and 6 (6.1%) non-allergic rhinitis patients. No association was noted between skin reactivity to Dermatophagoides farinae and the prevalence of specific IgE to CP or TA (p > 0.05).
The correlation between total IgE level and specific IgE level to CP and TA was poor
(r = 0.07, 0.04). ELISA inhibition test suggested specificity of IgE binding and cross-allergenicity between CP and TA. It is suggested that CP and TA can induce
IgE-mediated reaction in exposed patients and should be considered as important
causative allergens in respiratory allergy patients in Korea.
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KEYWORD
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